Lien-Yang Chou

Lien-Yang Chou’s Group

Principal Investigator 丨 Research Interests 丨 Selected Publications 丨 Group Eequipments丨 Group Members丨 Group Activities

Principal Investigator

Lien-Yang Chou，Assistant Professor | PI

E-mail：zhuoly@shanghaitech.edu.cn

Biography：

2011.9-2016.5 Boston College, Ph.D（Prof. Chia-Kuang Frank Tsung）

2016.8-2020.5 ShanghaiTech University, Research Assistant Professor

2018.8-2019.12 Stanford University, Visiting Scholar（Prof. Yi Cui）

2020.6-present ShanghaiTech University, Assistant Professor

Courses：Structural Chemistry, Synthetic Inorganic Chemistry

Research Interests

My research interests mainly focus on solving problems in interdisciplinary of material, chemistry, and biology. Specifically, the structure tunable nanoporous composites were rationally designed for the applications in catalysis, biology, and energy fields.

(1) Catalysis

My group develops new generation of metal-organic framework (MOF) composite materials for catalysis. We adjust the pore structure and functional groups of MOF and synergistically regulate the guest precious metals to control the activity and selectivity of specific heterogeneous catalysis. The focus of the research is on molecular level tuning of microporous composite materials and improving their performance based on the catalytic results.

Regulating the activity and selectivity of catalysts with nanopores

Various characterization techniques are used to explore the interface structure of the catalysts and investigate the relationship between microscopic structure and macroscopic performance. The catalytic mechanisms can be further constructed by simulation calculations.

Exploring the mechanism of composite catalysts through various characterization techniques

(2) Bioscience

We aim to integrate the materials science and synthetic biology to develop new engineered living materials (ELM). The interaction between biological and non-biological interfaces will be explored to develop the cutting-edge technologies such as biocatalysis, drug delivery and bio-batteries.

Drug delivery using porous composite materials

(3) Energy

MOF composite materials can be designed for the applications in fuel cells and solar cells using pore confinement and synergistic effects.

Using MOF composite materials to reduce poisoning of anode catalyst in fuel cells

Our group provides advanced equipment, excellent research environment and cozy working atmosphere. Please feel free to send your resume to zhuoly@shanghaitech.edu.cn.

Selected Publications

We have published over 40 papers in the prestigious international journals such as Nat. Energy，Nat. Comm.，J. Am. Chem. Soc.，Angew. Chem. Int. Edit.，Nano Lett.，Chem. Mater., Small and so on.

Representative papers after the establishment of Chou’s group:

1. Wu, M. ; Du, Y. ; Xu, H. ; Zhang, X. ; Ma, J.; Li, A.; Chou, L.-Y.* “Enzyme Surface Residues Direct Encapsulation into Metal-Organic Frameworks for Performance Regulation” Angew. Chem. Int. Ed. 2025, e202423741.（Enzyme Immobilization Hot Paper）

2. An, Y.; Hao, G.; Wang, X.; Zhou, L.; Wu, M.; Ma, J.; Chou, L.-Y.* “Inherent CeO2 Pore Structure Confined Pd for the Catalytic Performance Regulation” ACS Appl. Mater. Interfaces, 2025, 17(6), 9342.

3. Vo, T.-H.; Lin, S.-W.; Lin, M.-C.; Kuan, P.-Y.; Chen, J.-H.; Huang, H.-K.; Liu, W.-T.; Xu, H.; Li, A.; Hsu, Y.-A.; Wan, L.; Lam, P.-K.*; Chou, L.-Y.*; Yang, H.-C.*; Shieh, F.-K.* “Exploring Enzyme Encapsulation Efficiency in MOFs Using Eco-Friendly Approaches” ChemSusChem, 2024, e202401568.

4. Zhou L.; An Y.; Ma J.; Hao G.; Li Z.; Chen J.; Chou, L.-Y.* “A highly efficient synthetic strategy for de novo NP encapsulation into metal-organic frameworks: enabling further modulated control of catalytic properties” Chem. Sci., 2023, 14(45), 13126.

5. An, Y.; Chen, S.-Y.; Zhou, L.; Wang, B.; Hao, G.; Chen, J.; Wang, Y.; Zhang, H.; Peng, Z.; Yang, T.-C.; Yang, C.-M.; Chen, J.-L.; Tsung, C.-K.; Liu, Z.*; Chou, L.-Y.* “Sintering resistance of Pd single atoms on steam-modified ceria: deciphering the role of hydroxyl groups” J. Mater. Chem. A, 2023, 11(39), 21285.

6. Liu, Y. ; Wu, M. ; Kang, A. ; Zhang, X. ; Xie, R. ; Huang, Y.; Huang, J. ; Chou, L.-Y.*; Zhong, C.* “Living seed materials made by metal–organic framework‐encapsulated bacillus subtilis spore” Adv. Funct. Mater., 2023, 34(11), 2309288.

7. An, Y.; Chen, S.-Y.; Wang, B.; Zhou, L.; Hao, G.; Wang, Y.; Chen, J.; Tsung, C.-K.; Liu, Z.*; Chou, L.-Y.* “Controlling the metal-support interaction with steam-modified ceria to boost Pd activity towards low-temperature CO oxidation” J. Mater. Chem. A, 2023, 11(31), 16838.

8. Si, X.; Zhao, H.; Yi, B.; Zhou, L.;Ling, Y.; An, Y.; Wang, Y.; Lee, H.K.; Tsung, C.-K.; Ma, Y.*; Chou, L.-Y.*. “An archetype of the electron-unobstructed core-shell composite with inherent selectivity: conductive metal-organic frameworks encapsulated with metal nanoparticles” Nanoscale, 2022, 14(27), 9655. （2022 Nanoscale Hot Article）

9. Hsu, P.-H.; Chang, C.-C.; Wang, T.-H.; Lam, P.K.; Wei, M.-Y.; Chen, C.-T.; Chen, C.-Y.; Chou, L.-Y.*; Shieh, F.-K.* “Rapid Fabrication of Biocomposites by Encapsulating Enzymes into Zn-MOF-74 via a Mild Water-Based Approach” ACS Appl. Mater. Interfaces, 2021, 13(44), 52014.

10. Lo, W.-S^#; Chou, L.-Y.^#; Young, A.; Ren, C.; Goh, T.-W.; Williams, B.P.; Li, Y.; Chen, S.-Y.;Ismail, M. N.; Huang, W.;Tsung, C.-K. “Probing the Interface between Encapsulated Nanoparticles and Metal−Organic Frameworks for Catalytic Selectivity Control” Chem. Mater. 2021, 33(6), 1946.（ Highlighted as Front Cover）

11. Chou, L.-Y.; Ye, Y.; Lee, H.K.; Huang, W.; Xu, R.; Gao, X.; Chen, R.; Wu, F.; Tsung, C.-K.; Cui, Y. “Electrolyte-Resistant Dual Materials for the Synergistic Safety Enhancement of Lithium-Ion Batteries” Nano Lett. 2021, 21(5), 2074.

Representative papers before the establishment of Chou’s group:

1. Ye, Y. ^#; Chou, L.-Y. ^#; Liu, Y.; Wang, H.; Lee, H.K.; Huang, W.; Wan, J; Liu, K.; Zhou, G.; Yang, Y.; Yang, A.; Xiao, X.; Gao, X.; Boyle, D.B.; Chen, H.; Zhang, W.; Kim, S.C.; Cui, Y. “Ultralight and fire-extinguishing current collectors for high-energy and high-safety lithium-ion batteries” Nat. Energy, 2020, 5(10), 786.（ Highlighted as Front Cover）

2. Chen, S.-Y.; Lo, W.-S; Huang, Y.-D.; Si, X.; Liao, F. -S.; Lin, S.-W.; Williams, B. P.; Sun, T.-Q.; Lin, H.-W.; An, Y.; Sun. T.; Ma, Y.; Yang, H.-C.*; Chou, L.-Y.*; Shieh, F.-K.*; Tsung, C.-K.* “Probing Interactions between Metal−Organic Frameworks and Freestanding Enzymes in a Hollow Structure” Nano Lett. 2020, 20, 9, 6630.

3. Liu, X.-Y.; Lo, W.-S; Wu, C.; Williams, B. P.; Luo, L.; Li, Y; Chou, L.-Y.*;Lee, Y.*; Tsung, C.-K.* ‘Tuning Metal−Organic Framework Nanocrystal Shape through Facet-Dependent Coordination” Nano Lett. 2020, 20(9), 6630.

4. Luo, L.; Lo, W.-S.; Si, X.; Li, H.; An, Y.; Qin, X.; Zhao, H; Zhu, Q; Chou, L.-Y.*; Li, T.*; Tsung, C.-K.* ”Directional Engraving within Single Crystalline Metal−Organic Framework Particles via Oxidative Linker Cleaving” J. Am. Chem. Soc. 2019, 141(51), 20365.

5. Wei, T.-H.; Wu, S.-H.; Huang, Y.-D.; Lo, W.-S.; Williams, B. P.; Yang, H.-C.; Yu-Shen Hsu, Y.-S.; Chou, L.-Y.*; Tsung, C.-K.*; Shieh, F.-K.* ”Rapid mechanochemical encapsulation of biocatalysts into robust metal–organic frameworks” Nat. Comm. 2019, 10, 5002. （2019 Editors' Highlights on Organic Chemistry and Chemical Biology）

6. Wu, C.^#; Chou, L.-Y.^#; Lo, W.-S.; Long, L.; Si, X.; Tsung, C.-K.; Li, T. “Structural Control of Uniform MOF-74 Microcrystals for the Study of Adsorption Kinetics” ACS Appl. Mater. Interfaces, 2019, 11(39), 35820.

7. Liu, X.-Y.; Zhang, F.; Goh, T.-W.; Li, Y.; Shao, Y.-C.; Luo, L.; Huang, W.; Long, Y.-T.; Chou, L.-Y.*; Tsung, C.-K.* “Using a Multi-Shelled Hollow Metal–Organic Framework as a Host to Switch the Guest-to-Host and Guest-to-Guest Interactions” Angew. Chem. Int. Edit. 2018, 57(8), 2110.

8. Giustra, Z. X.^#; Chou, L. -Y.^#; Tsung, C.-K.; Liu, S.-Y. “Kinetics of −CH₂CH₂− Hydrogen Release from a BN-cyclohexene Derivative” Organometallics, 2016, 35(15), 2425.

9. Chou, L. -Y.; Hu, P.; Zhuang, J.; Morabito, J. V.; Ng K. –C.; Kao Y. –C.; Wang, S. -C.; Shieh, F. -K.; Kuo, C. -H.; Tsung, C.-K. “Formation of hollow and mesoporous structures in single-crystalline microcrystals of metal–organic frameworks via double-solvent mediated overgrowth” Nanoscale, 2015, 7(46), 19408.

10. Zhuang, J.^#; Chou, L. -Y.^#; Sneed, B. T.; Cao, Y.; Hu, P.; Feng, L.; Tsung, C.-K. ”Surfactant-Mediated Conformal Overgrowth of Core–Shell Metal–Organic Framework Materials with Mismatched Topologies” Small, 2015, 11(41), 5551.

11. Morabito, J. V.^#; Chou, L. -Y.^#; Li, Z.; Manna, C. M.; Petroff, C. A.; Kyada, R.; Palomba, J, M.; Byers, J. A.; Tsung, C.-K. ”Molecular Encapsulation beyond the Aperture Size Limit through Dissociative Linker Exchange in Metal−Organic Framework Crystals” J. Am. Chem. Soc. 2014, 136(36), 12540.

12. Chou, L.-Y.; Liu, R.; He, W.; Geh, N.; Lin, Y.; Hou, E. Y. F.; Wang, D.; Hou, H. J. M. ”Direct oxygen and hydrogen production by photo water splitting using a robust bioinspired manganese-oxo oligomer complex/tungsten oxide catalytic system” Int. J. Hydrogen Energy, 2012, 37(10), 8889.