Jingjing Xie


Jingjing Xie Research Group

Group Leader  Research  Selected Publications 


Group Leader





Institute: School of Physical Science and Technology

Research Area: Biomolecular condensates, Chemical Biology

Contact Info: xiejj@shanghaitech.edu.cn


2009.9-2013.6, B.S., Pharmacy, China Pharmaceutical University

2013.9-2020.1, Ph.D., Cell Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

2020.1-2022.1, Research Associate, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

2022.2-2023.6, Research Investigator, Etern Biopharma

2023.7-2023.12, Postdoctoral Fellow, Memorial Sloan Kettering Cancer Center

2023.12-current, Assistant ProfessorPI, School of Physical Science and Technology, ShanghaiTech University




Research Interests




Our research focus on investigating the condensate dysregulation mechanisms underlying biological processes and disease progression, and understanding the physical principles of condensates formation to gain insight into manipulating synthetic condensates for further applications.



Selected Publications




1. Zhu, T. #, Xie, J. #, He, H. #, Li, H. #, Tang, X., Wang, S., Li, Z., Tian, Y., Li, Y., Zhu, J. *, Zhu, G. *, Phase separation underlies signaling activation of oncogenic NTRK fusions. Proc. Natl. Acad. Sci. USA. 2023,120(42): e2219589120. doi: 10.1073/pnas.2219589120.

2. Xie, J. #, He, H. #, Kong, W., Li, Z., Gao, Z., Xie, D., Sun, L., Fan, X., Jiang, X., Zheng, Q., Li, G., Zhu, J. *, Zhu, G. *, Targeting androgen receptor phase separation to overcome antiandrogen resistance. Nat. Chem. Biol. 2022,18(12): 1341-1350. (Cover story, News& views) 

3. Zhu, G. #, Xie, J. #, Fu, Z., Wang, M., Zhang, Q., He, H., Chen, Z., Guo, X., Zhu, J. *, Pharmacological inhibition of SRC-1 phase separation suppresses YAP oncogenic transcription activity. Cell Res. 2021,31(9):1028-1031. 

4. Xie, J.#, Zhu, G. #, Gao, M. #, Xi, J., Ma, X., Yan, Y., Wang, Z., Xu, Z-J., Chen, H-J., Hao, H., Yao, Z. *, Zhu, J. *, An artemisinin derivative ART1, induces ferroptosis by targeting the HSD17B4 protein essential for lipid metabolism and direct induction of lipid peroxidation. CCS Chem. 2021,3,664-677.

5. Zhu, G. #, Xie, J.#, Kong, W. #, Xie, J. #, Li, Y., Du, L., Zheng, Q., Sun, L., Guan, M., Li, H., Zhu, T., He, H., Liu, Z., Xia, X., Kan, C., Tao, Y., Hong, S., Li, D., Wang, S., Yu, Y., Yu, Z., Zhang, Z., Liu, C. *, Zhu, J. *, Phase separation of disease-associated SHP2 mutants underlies MAPK hyperactivation. Cell. 2020, 183, 1–13. 

6. Xie, J. #, Si, X. #, Gu, S., Wang, M., Shen, J., Li, H., Shen, J., Li, D., Fang, Y., Liu, C. *, Zhu, J. *, Allosteric inhibitors of SHP2 with therapeutic potential for cancer treatment. J. Med. Chem. 2017, 60,10205-10219.