Huaidong Jiang


Huaidong Jiang    Professor
InstituteSchool of Physical Science and Technology
Research AreaCoherent diffraction imaging, crystal materials

Prof. Jiang received his PhD degree in materials science from the Shandong University in 2003. He then pursued his research in the National University of Singapore and the University of California Los Angeles as a postdoctoral research fellow and assistant research professor from 2003 to 2010. He joined Shandong University as a professor in 2010. Since September of 2016, he joined the School of Physical Science and Technology of ShanghaiTech University as a professor.

Research Interests
We are interested in high-resolution quantitative imaging and related research with X-ray free electron lasers, synchrotron radiation sources and electron microscopes. Currently our research focuses on the development of new diffraction imaging technologies and methods for X-ray free electron lasers, three-dimensional high-resolution microscopies and applications, synthesis of functional materials, microstructure and mechanism.

Selected Publications
  1. X. L. Li, N. Q. Gong, F. L. Tian, S. K. Zhang, Y. X. Zhang, Y. F. Wang, G. C. Qing, Y. C. Wang, F, Z. Li, Y. H. Xu, L. L. Zhang, J. J. Wang, Q. K. Ni, Y. L. Gan, C. J. Gu, H. D. Jiang, X. X. Huang, X. H. Shi, T. C. Zhang, Y. Wu, X. J. Liang, “Suppression of cytokine release syndrome during CAR-T-cell therapy via a subcutaneously injected interleukin-6-adsorbing hydrogel”, Nature Biomedical Engineering 7, 1129-1141 (2023).

  2. Z. Dong#, E. Zhang#, Y. Jiang, Q. Zhang, A. Mayoral, H. Jiang*, Y. Ma*. “Atomic-level imaging of zeolite local structures using electron ptychography”, J. Am. Chem. Soc. 145, 6628-6632 (2023).

  3. Z. Y. Du, Z. S. He, J. D. Fan, Y. G. Huo, B. He, Y. R. Wang, Q. Q. Sun, W. C. Niu, W. C. Zhao, L. N. Zhao, P. Cao, K. Cao, D. F. Xia, Q. Yuan, X. J. Liang, H. D. Jiang*, Y. Gong*, X. Y. Gao*, “Au4 cluster inhibits human thioredoxin reductase activity via specifically binding of Au to Cys189”, Nano Today 47, 101686 (2022).

  4. J. Fan, Y. Tong, Y. Nie, Z. Gao, B. He, H. Luan, D. Lu, J. Zhang, D. Zhang, X. Yuan, J. Chen, Z. Guo, T. Liu, M. Zhang, C. Feng, H. Deng, B. Liu, Z. Zhao, Z. Liu, H. Jiang*, “First commissioning results of the coherent scattering and imaging endstation at the Shanghai soft X-ray free-electron laser facility”, Nuclear Science and Techniques 33, 114 (2022). (Cover article)

  5. A. Guo#, J. Zhang#, B. He, A. Li, T. Sun, W. Li, J. Wang, R. Tai, Y. liu, Z. Qian, J. Fan*, A. Sali, R. Stevens, H. Jiang*, “Quantitative, in situ visualization of intracellular insulin vesicles in pancreatic beta cells”, Proc Natl Acad Sci USA.119(32): e2202695119 (2022).

  6. T. Li, B. He, X. Zhang, J. Fan*, L. Gao, Z. Sun, J. Zhang, A. Guo, D. Pan, X. Yin, Y. Tong, C. Song, Y. Kohmura. M. Yabashi, T. Ishikawa, X. Gao*, H. Jiang*, “Three-Dimensional Quantitative Coherent Diffraction Imaging of Staphylococcus aureus Treated with Peptide-Mineralized Au-Cluster Probes”, Anal. Chem. 94, 13136-13144 (2022). (Supplementary cover article)

  7. D. Pan, J. D. Fan*, Z. Z. Nie, Z. B. Sun, J. H. Zhang, Y. J. Tong, B. He, C. Y. Song, Y. Kohmura, M. Yabashie, T. Ishikawae, Y. Q. Shen, H. D. Jiang*, “Quantitative analysis of radiation effect on structure of mitochondria using coherent diffraction imaging with clustering algorithm”, IUCrJ 9, 223-230 (2022).

  8. Z. S. He#, F. Ye#, C. Y. Zhang#, J. D. Fan#, Z. Y. Du, W. C. Zhao, Q. Yuan, W. C. Niu, F. P. Gao, B. He, P. Cao, L. N. Zhao, X. J. Gao, X. F. Gao, B. Sun, Y. H. Dong, J. C. Zhao, J. X. Qi, X. J. Liang, H. D. Jiang*, Y. Gong*, W. J. Tan*, X. Y. Gao*, “A comparison of Remdesivir versus gold cluster in COVID-19 animal model: A better therapeutic outcome of gold cluster”, Nano Today 44, 101468 (2022).

  9. A. M. Guo, J. H. Zhang, Y. Wang, J. Fan, B. He, J. Wang, R. Z. Tai, X. J. Liang*, H. D. Jiang*, “Nanoscale detection of subcellular nanoparticles by X-ray diffraction imaging for precise quantitative analysis of whole cancer cells”, Anal. Chem.93. 5201-5210 (2021). (Supplementary cover article)

  10. C. Y. Zhang, S. K. Yao, C. Xu, Y. N. Chang, Y. B. Zong, K. Zhang, X. Z. Zhang, L. J. Zhang, C. Y. Chen, Y. L. Zhao, H. D. Jiang*, X. Gao*, Y. L. Wang*, “3D imaging and quantification of the integrin at a single-cell base on a multisignal nanoprobe and synchrotron radiation soft X-ray tomography microscopy”, Anal. Chem. 93, 1237-1241 (2021).

  11. C. Jung, Y. Ihm, D. H. Cho, H. Lee, D. Nam, S. Kim, I. T. Eom, J. Park, C. Kim, Y. Kim, J. D. Fan, N. J. Ji, J. R Morris, S. Owada, K. Tono, J. H. Shim, H. D. Jiang, M. Yabashi, T. Ishikawa, D. Y. Noh, C. Y. Song, “Inducing thermodynamically blocked atomic ordering via strongly driven nonequilibrium kinetics”Science Advances 7, eabj8552 (2021).

  12. L. Gao, Y. Zhang, L. N, Zhao, W. C. Niu, Y. H. Tang, F. P. Gao, P. Cai, Q. Yuan, X. Y. Wang, H. D. Jiang, X. Y. Gao, “An artificial metalloenzyme for catalytic cancer-specific DNA cleavage and operando imaging”, Science Advances 6, eabb1421 (2020)

  13. A. Rana#, J. H. Zhang#, M. Pham, A. Yuan, Y. H. Lo, H. D. Jiang, S. Osher, J. Miao, “Potential of attosecond coherent diffractive imaging”, Phys. Rev. Lett. 125, 086101 (2020). (Highlighted by Science 369, 1337, 2020)

  14. C. Y. Zhang, L. Gao, Q. Yuan, L. N. Zhao, W. C. Niu, P. J. Cai, J. J. Li, X. Han, Z. He, F. P. Gao, Y. L. Wang, H. D. Jiang, Z. F. Chai, X. Y. Gao, “Is GSH Chelated Pt Molecule Inactive in Anti‐Cancer Treatment? A Case Study of Pt6GS4”, Small 16, e2002044 (2020).

  15. N. Q. Gong, X. W. Ma, X. Ye, Q. F. Zhou, X. Chen, X. L. Tan, S. K. Yao, S. D. Huo, T. B. Zhang, S. Chen, X. Teng, X. X. Hu, J. Yu, Y. L. Gan, H. D. Jiang, J. Li, X. J. Liang, “Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment”, Nature Nanotechnology 14, 379-387 (2019).

  16. Z. Q. Li, P. F. Zhu, J. M. Ding, N. J. Ji, Y. Chen, Z. Y. Wang, X. L Duan*, H. D. Jiang*, “Increased concentration of Yb3+ and high crystal field strength in RbTiOPO4:Ta single crystal with optimized growth”, Crystal Growth & Design 19, 7143-7152 (2019).

  17. Z. B. Sun, J. D. Fan, H. Y. Li, H. J. Liu, D. W. Nam, C. Kim, Y. H. Kim, Y. B. Han, J. H. Zhang, S. K. Yao, J. H. Park,S. N. Kim, K. Tono, M. Yabashi, T. Ishikawa, C. Y. Song, C. H. Fan, H. D. Jiang*, “Necessary Experimental Conditions for Single-Shot Diffraction Imaging of DNA-Based Structures with X-ray Free-Electron Lasers”, ACS Nano 12, 7509-7518 (2018).

  18. S. K. Yao, J. D. Fan, Z. Y. Chen, Y. B. Zong, J. H. Zhang, Z. B. Sun, L. J. Zhang, R. Z. Tai, Z. Liu, C. Y. Chen, H. D. Jiang*, “Three-dimensional ultrastructural imaging reveals the nanoscale architecture of mammalian cells”, IUCrJ 5, 141-149 (2018). (Cover article)

  19. R. Mani, S. K. Gupta, P. S. Ghosh, H. D. Jiang*, “Yellow Emission from Low Coordination Site of Sr2SiO4:Eu2+, Ce3+: Influence of Lanthanide Dopants on the Electron Density and Crystallinity in Crystal Site Engineering Approach”, Chemistry - A European Journal 24, 16149-16159 (2018).

  20. B. J. Ma, Y. Wu, S. Zhang, S. C. Wang, J. C. Qiu, L. L. Zhao, D. D. Guo, J. Z. Duan, Y. H. Sang, L. L. Li, H. D. Jiang*, H. Liu*, “Terbium-Aspartic Acid Nanocrystals with Chirality-Dependent Tunable Fluorescent Properties”, ACS Nano 11, 1973-1981 (2017).

  21. B. J. Ma, S. Zhang, R. Y. Liu, J. C. Qiu, L. L. Zhao, S. C. Wang, J. Li, Y. H. Sang, H. D. Jiang*, H. Liu*, “Prolonged fluorescence lifetime of carbon quantum dots by combining with hydroxyapatite nanorods for bio-applications”, Nanoscale 9, 2162-2171 (2017).

  22. Y. B. Zong, S. K. Yao, G. W. Crawford, H. Fang, J. F. Lang, J. D. Fan, Z. B. Sun, Y. Liu, J. H. Zhang, X. L. Duan, G. Z. Zhou, T. Q. Xiao, F. S. Luan, Q. Wang, X. X. Chen*, H. D. Jiang*, “Selection for oil content during soybean domestication revealed by x-ray tomography of ancient beans”, Scientific Reports 7, 43595 (2017).

  23. Y. B. Zong, S. K. Yao, J. F. Lang, X. X. Chen, J. D. Fan, Z. B. Sun, X. L. Duan, N. N. Li, H. Fang, G. Z. Zhou, T. Q. Xiao, A. G. Li, H. D. Jiang*, “Structural and compositional analysis of a casting mold sherd from ancient China”, PLoS ONE 12, 0-e0174057 (2017).

  24. J. D. Fan, Z. B. Sun, Y. L. Wang, J. Park, S. Kim, M. Gallagher-Jones, Y. Kim, C. Song, S. K. Yao, J. Zhang, J. H. Zhang, X. L. Duan, K. Tono, M. Yabashi, T. Ishikawa, C. H. Fan, Y. L. Zhao, Z. F. Chai, X. Y. Gao*, T. Earnest, H. D. Jiang*, “Single-pulse enhanced coherent diffraction imaging of bacteria with an X-ray free-electron laser”, Scientific Reports 6, 34008 (2016).

  25. S. K. Yao, J. D. Fan, Y. B. Zong, Y. He, G.Z. Zhou, Z. B. Sun, J. H. Zhang, Q. J. Huang, T. Q. Xiao, H. D. Jiang*, “Equally sloped X-ray microtomography of living insects with low radiation dose and improved resolution capability”, Applied Physics Letters 108, 123702 (2016).

  26. J. H. Li, J. C. Qiu, W. B. Guo, S. Wang, B. J. Ma, X. N. Mou, Mi. Tanes, H. D. Jiang*, H. Liu*“Cellular internalization of LiNbO3 nanocrystals for second harmonic imaging and the effects on stem cell differentiation”, Nanoscale 8, 7416-7422 (2016).

  27. H. D. Jiang, “Cryo-coherent diffractive imaging of biological samples with X-ray free-electron lasers”, Acta Cryst. A72, 177–178 (2016).

  28. J. D. Fan, Z. B. Sun, J. Zhang, Q. J. Huang, S. k. Yao, Y. b. Zong, Y. Kohmura, T. Ishikawa, H. Liu, H. D. Jiang*Quantitative Imaging of Single Unstained Magnetotactic Bacteria by Coherent X-ray Diffraction MicroscopyAnalytical Chemistry 87, 5849-5853 (2015).

  29. J. D. Fan, Y. Zhang, N. J. Ji, X. L. Duan, H. liu, J. Y. Wang, H. D. Jiang*Hierarchical structures of self-assembled hybrid calcium carbonate: nucleation kinetic studies on biomineralizationCrystEngComm. 17, 5372-5376, (2015). (Inside front cover article)

  30. J. Zhang, J. D. Fan, J. H. Zhang, Z. B. Sun, Q. J. Huang, H. D. Jiang*, “Three-dimensional coherent diffraction imaging of Mie-scattering spheres by laser single-orientation measurement”, Chin. Phys. B 24, 094201 (2015). (Suggested by editors)

  31. H. D. Li, Y. H. Sang, S. Chang, X. Huang, Y. Zhang, R. S. Yang,H. D. Jiang, H. Liu, Z. L. Wang, Enhanced Ferroelectric-Nanocrystal-Based Hybrid Photocatalysis by Ultrasonic-Wave-Generated Piezophototronic Effect, Nano letters. 15 (4), 2372-2379 (2015)

  32. R. Xu, H. D. Jiang, C. Song, J. A. Rodriguez, Z. Huang, C.-C. Chen, D. Nam, J. Park, M. Gallagher-Jones, S. Kim, S. Kim, A. Suzuki, Y. Takayama, T. Oroguchi, Y. Takahashi, J. Fan, Y. Zou, T. Hatsui, Y. Inubushi, T. Kameshima, K. Yonekura, K. Tono, T. Togashi, T. Sato, M. Yamamoto, M. Nakasako, M. Yabashi, T. Ishikawa and J. Miao, Single-shot three-dimensional structure determination of nanocrystals with femtosecond X-ray free-electron laser pulses, Nature Commun. 5, 4061 (2014).

  33. H. D. Jiang, R. Xu, C.-C. Chen, W. Yang, J. Fan, X. Tao, C. Song, Y. Kohmura, T. Xiao, Y. Wang, Y. Fei, T. Ishikawa, W. L. Mao, and J. Miao, “Three-dimensional coherent x-ray diffraction imaging of molten iron in mantle olivine at nanoscale resolution”, Phys. Rev. Lett., 110, 205501 (2013).

  34. J. Tian, Y. H. Sang, G. W. Yu , H. D. Jiang , X. N. Mu , H. Liu, “A Bi2WO6‐Based Hybrid Photocatalyst with Broad Spectrum Photocatalytic Properties under UV, Visible, and Near‐Infrared Irradiation”, Advanced Materials 25, 5075-5080 (2013).

  35. H. D. Jiang, C. Song, C. C. Chen, R. Xu, K. Raines, B. Fahimian, C. H. Lu, T. K. Lee, A. Nakashima, J. Urano, T. Ishikawa, F. Tamanoi, J. Miao “Quantitative 3D imaging of whole, unstained cells at a resolution of 50 - 60 nm by X-ray diffraction microscopy”, Proc. Natl. Acad. Sci. USA, 107, 11234-11239 (2010).

  36. K. S. Raines, S. Salha, R. Sandberg, H. D. Jiang, J. A. Rodríguez, B. P. Fahimian1, H. C. Kapteyn, JDu, J. Miao Ankylography: three-dimensional structure determination from a single view”, Nature 463, 214-217 (2010). (Highlighted byNature Methods7, 96, 2010)

  37. H. D. Jiang, D. Johnson,C. Song, B. Amirbekian, Y. Kohmura, Y. Nihino, Y. Takahashi,T. Ishikawa, J. Miao “Nanoscale Imaging of Mineral Crystals inside Biological Composite Materials Using X-ray Diffraction Microscopy”, Phys. Rev. Lett. 100, 038103 (2008).

  38. C. Song, H. D. Jiang, A. Mancuso, B. Amirbekian, L. Peng, R. Sun, S. S. Shah, Z. H. Zhou, T. Ishikawa, J. Miao “Quantitative Imaging of Single, Unstained Viruses with Coherent X Rays”, Phys. Rev. Lett. 101, 158101 (2008).

  39. C. Song, R. Bergstrom, D. Ramunno-Johnson, H. D. Jiang, D. Paterson, M. D. de Jonge, I. McNulty, J. Lee, K. Wang, J. Miao “Nanoscale Imaging of Buried Structures with Elemental Specificity Using Resonant X-ray Diffraction Microscopy”, Phys. Rev. Lett. 100, 025504 (2008). (Highlighted byNature Nanotechnology3, 126, 201018)

  40. H. D. Jiang, X. Y. Liu, G. Zhang, Y. Li Kinetics and template nucleation of self-assembled hydroxyapatite nanocrystallites by chondroitin sulfate,” J. Biol. Chem. 280, 42061-42066 (2005).

  41. H. D. Jiang, X. Y. Liu “Principles of mimicking and engineering the self-organized structure of hard tissues,”J. Biol. Chem. 279 (40), 41286-41293 (2004).