王平鸾

课题组长  Group Leader

Institute: School of Physical Science and Technology Research Area: Molecular Targeting, Molecular Therapeutics, Chemical Biology Contact Info: wangpl1@shanghaitech.edu.cn Biography: 2009.9-2013.6, B.S., Chemistry, Lanzhou University 2013.8-2018.6, Ph.D., Organic Chemistrty, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 2018.7-2019.4, Research Associate, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 2019.5-2024.4, Postdoctoral Fellow, University of Chicago 2024.5-2026.1, Research Investigator, University of Chicago 2026.1-current, Assistant Professor、PI, School of Physical Science and Technology, ShanghaiTech University

研究介绍  Research Interest

Our research interests are centered on Chemical Biology and Molecular Targeting. We seek to understand and manipulate RNA and proteins using small molecules, investigate the biological and disease mechanisms of modified nucleobases, and explore the roles of cell-surface RNA. By integrating high-quality chemical biology data with machine learning, we aim to translate these fundamental discoveries into Molecular Therapeutics.

代表性论文  Select Publications

1.Wang, P. #, Ye, C. #, Zhao, M. #, Jiang, B., He, C.*, Small-molecule-catalysed deamination enables transcriptome-wide profiling of N6-methyladenosine in RNA. Nat. Chem. 2025,17: 1042-1052.

2. Pomaville, M. #, Chennakesavalu, M. #, Wang, P. #, Jiang, Z. #, Sun, H., Ren, P., Borchert, R., Gupta, V., Gupta, V., Ye, C., Ge, R., Zhu, Z., Brodnik, M., Zhong, Y., Salwen, H., George, R. E., Krajewska, M., Chlenski, A. Applebaum, M. A., He, C., Cohn, S. L *, Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation. Cell Rep. 2024, 43:114165.

3.Wang, P. #, Gao, Y. #, Ma, D. *, Divergent Entry to Gelsedine-Type Alkaloids: Total Syntheses of (-)-Gelsedilam, (-)-Gelsenicine, (-)-Gelsedine, and (-)-Gelsemoxonine. J. Am. Chem. Soc. 2018, 140:11608-11612.

4. Zhang, H#, Dong, Z., Yang, Y., Wang, P., Hui, X *, N-Heterocyclic Carbene-Catalyzed Stereoselective Cascade Reaction: Synthesis of Functionalized Tetrahydroquinolines. Org. Lett.2013, 15, 4750–4753.

5. Weng, X. #, Gong, J. #, Chen, Y. #, Wu, T. #, Wang, F., Yang, S., Yuan, Y., Luo, G., Chen, K., Hu, L., Ma, H., Wang, P., Zhang, Q. C. *, Zhou, X. *, He, C. *, Keth-seq for transcriptome-wide RNA structure mapping. Nat. Chem. Biol. 2020, 16, 489-492. 

6. Ge, R. #, Ye, C. #, Peng, Y., Dai, Q., Zhao, Y., Liu, S., Wang, P., Hu, L. *, He, C. *, m6A-SAC-seq for quantitative whole transcriptome m6A profiling.  Nat. Protoc. 2023, 18, 626-657.

7. Xiao, Y. #, Chen, Y. #, Zou, Z., Ye, C., Dou, X., Wu, J., Liu, C., Liu, S., Yan, H., Wang, P., Zeng, T., Liu, Q., Fei, J., Tang, W., He, C. *, Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing. Nat. Method2024, 21, 247-258.

8. Wu, T. #, Cheng, A. Y. #, Zhang, Y., Xu, J., Wu, J., Wen, L., Li, X., Liu, B., Dou, X., Wang, P., Zhang, L., Fei, J., Li, J., Ouyang, Z. *, He, C. *, KARR-seq reveals cellular higher-order RNA structures and RNA–RNA interactions. Nat.Biotechnol.2024, 42, 1909–1920.

9. Ross, M. O., Xie, Y., Owyang, R. C., Ye, C., Zbihley, O. N. P., Lyu, R., Wu, T., Wang, P., Karginova, O., Olopade, O. I., Zhao, M., He, C. *, PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression. Nat. Comm.2024, 15: 6947.

10. Feng, X. #, Cui, X. #, Zhang, L. #, Ye, C., Wang, P., Zhong, Y., Wu, T., Zheng, Z., He, C. *, Sequencing of N6-methyl-deoxyadenosine at single-base resolution across the mammalian genome. Mol. Cell2024, 84, 596-610.E6.

11. Lyu, R., Gao, Y., Wu, T., Ye, C., Wang, P., He C., Quantitative analysis of cis-regulatory elements in transcription with KAS-ATAC-seq. Nat. Comm. 2024, 15: 6852.

12. Liu, B., Wu, T., Maio, B. A., Ji, F., Liu, S., Wang, P., Zhao, Y., Zhong, Y., Sundaram, A., Zeng, T., Majcherska-Agrawal, M., Keenan, R. J., Pan, T. *, He, C. *, snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification. Cell2025, 188, 465-483.e22.

13. Zhao, Y., Sun, H., Li, W., Ye, C., Dou, X., Peng, Y., Wu, T., Wang, P., Ju, C., Liu, S., Zhong, Y., Dai, Q., Pajdzik, K., He, C., Pseudouridylation of 7SK by PUS7 regulates Pol II transcription elongation. Nat. Comm.2025, 16: 9595.

14. Shafik, A. M. *, Peng, Y., Zhang, Z., Chang, C., Wang, P., Lim, J., Song, H., He, C., Chen, M. *, Jin, P. *, Multi-region m⁶A epitranscriptome profiling of the human brain reveals spatial and temporal variation and enrichment of disease-associated loci. Nat. Neurosci.2025, 29, 195-205.

15. Chen, D., Wang, L., Wen, C., Piffko, A., Bugno, J., Yu, X., Wang, P., Ji, F., Naccasha, E. Z., Wang, J., Huang, X., Chmura, S. J., Pitroda, S. P., He, C. *, Liang, A. L. *, Weichselbaum, R. R. *, Radiotherapy induces YTHDF2 in dendritic cells impairing cross-presentation and T cell function. J. Exp. Med.2026, 223: e20250641.

本组成员  Group Members