郑宜君课题组介绍
Our research focus on developing advanced dynamic biomaterials mimicking extracellular matrix to understand how cells interact with their environment and to gain insight into the manipulating mechanism of cell functions.
In the current stage, we are particularly interested on two topics:
(1) Molecular tools for cellular mechanosensing.
One of the central challenges in cellular mechanotransduction is the understanding of the molecular mechanisms that enable cells to modulate their mechanical responses and to sense and actively direct the biophysical properties of the ECM. To elucidate these fundamental mechanisms, cellular mechanotransduction should be studied at molecular levels. We develop molecular tools that can apply or detect forces at individual receptors within readily formed cell-ECM or cell-cell contacts.
(2) Synthetic yet 'living' biomaterials with active, adaptive and autonomous properties.
We established ways to emulate “living” properties within synthetic chemical frameworks through non-equilibrium chemical reaction networks with energy dissipation, kinetic control and feedback loops.
Welcome undergrads and graduate students with different backgrounds to join the group. We are recruiting POSTDOCs (with organic chemistry, polymer chemistry or biomaterials background). Feel free to contact the PI.
1. Y. Zhao# , B. Li,# , X. Fu# , P. Zhao , Y. Zhao , W. Zhou , Y. Lu , Y. Zheng*, Autocatalytic Reactions Networks: A Pathway to Spatial Temporal Mastery in Dynamic Materials, Angew. Chem. Int. Ed. 2024, e202415582
2. Y. Lu, C.Chen, H. Li, P. Zhao, Y. Zhao, B. Li, W. Zhou, G. Fan,D. Guan*,Y. Zheng*, Visible Light-Responsive Hydrogels for Cellular Dynamics and Spatiotemporal Viscoelastic Regulation,Nat. Commun., 2024, Accepted
3. P. Zhao#, Y. Zhao# , Y. Lu, L. Xu, B. Li, Y. Zhao, W. Zhou, P. Yan, Y. Wang, K. Cao, Y. Zheng*, Non-Equilibrium Dissipative Assembly with Switchable Biological Functions, Angew. Chem. Int. Ed. 2024, e202409169.
4. P. Zhao#, L. Xu#, B. Li, Y. Zhao, Y. Zhao, Y. Lu, M. Cao, G. Li, T. Weng, H. Wang, Y. Zheng*, Non-Equilibrium Assembly of Atomically-Precise Copper Nanoclusters, Adv. Mater. 2024, 2311818.
5. Y. Zhao#, P. Zhao#, J. Zhang#, Y. Zhao, B. Li, G. Hao, Y. An, W. Zhou, Y. Lu, L. Chou, Y. Zheng*, CCS Chem. 2023, 5, 1-11.
6. W. Zhou#, G. Shi#, P. Zhao, G. Zhang, P. Yang, B. Li, B. Li, X. Wan*, Y. Zheng*, Dynamic helical cationic polyacetylenes for fast and highly efficient killing of bacteria, Acta. Biomater., 2023,161, 134-143.
7. N. Cheng, Y. Zhang, Y. Wu, B. Li, H. Wang, S. Chen, P. Zhao, J. Cui, X. Shen, X. Zhu, Y. Zheng*, Hydrogel platform capable of molecularly resolved pulling on cells for mechanotransduction, Material Today Bio, 2022,17,100476.
8. J. Zhang, J. Liu, H. Li, X. Li, Y. Zhao, P. Zhao, J. Cui, B. Yang, Y. Song, Y. Zheng*, Programming hydrogels with complex transient behaviors via autocatalytic cascade reactions, ACS Appl. Mater. Interfaces 2022, 14, 17, 20073–20082.
9. J. Feng, Y. Zheng, Q. Jiang, M.K.Wlodarczyk-Biegun, S. Person, A. del Campo, Elastomeric optical waveguides by extrusion printing, Advanced Materials Technologies, 2022, 2101539.
10. B. Li, J. Blass, M. Han, J. Zhang, Y. Zheng, Q. Jiang, R. Bennewitz, A. del Campo, Molecular stiffness cues of an interpenetrating network hydrogel for cell adhesion, Materals Today Bio, 2022, 15, 100323.
11. Y. Zheng#, M. K.L. Han#, R.g Zhao#, J. Blass#, J. Zhang, D.W. Zhou, J. Colard-Itté, D. Dattler, A. Çolak, M. Hoth, A. J. García, B. Qu, R. Bennewitz, N. Giuseppone, A. del Campo*, Optoregulated force application to cellular receptors using molecular motors, Nat. Commun. 2021, 12, 3580.
12. L. Yang, S. Dong, W. Zhou, Q. Wu, Y. Zheng, J.Cui*, Calenderable supramolecular perfluorogels for facile fabrication of slippery coatings, Chem. Eng. J. 2021, 127901.
13. J. Feng, Y. Zheng, S. Bhusari, M. Villiou, S. Pearson, A. del Campo*, Printed degradable optical waveguides for guiding light into tissue, Adv. Funct. Mater. 2020, 2004327.
14. Y. Zheng*, Z. Chen, Q. Jiang, J. Feng, S. Wu and A. del Campo*,Nanoscale, 2020, 12, 13654.
15. F. Puza, Y. Zheng*, L. Han, L. Xue and J.Cui*, Physical entanglement hydrogels: ultrahigh water content but good toughness and stretchability, Polym. Chem., 2020, 11, 2339.
Before joining ShanghaiTech:
Y. Zheng*, M. Han, Q. Jiang, J. Feng, Bin. Li, A. del Campo, “4D hydrogels for dynamic cell culture with orthogonal, wavelength-regulated stiffening and cell adhesiveness”, Mater. Horiz. 2019, 20, 111-116.
Y. Zheng, A. Farrukh, A. del Campo “Optoregulated Biointerfaces to Trigger Cellular Responses”, Langmuir, 2018, 34, 48,14459.
Y. Zheng*, D. Wang, J. Cui, M. Mezger, G. K. Auernhammer, K. Koynov, H.-J. Butt, T. Ikeda, “Redox-Responsive and Thermoresponsive Supramolecular Nanosheet Gels with High Young's Moduli”, Macromol. Rapid Commun. 2018, 39, 1800282.
Y. Zheng, X. Liu, J. Xu, H. Zhao, X. Hou, J. Cui “Thermo-responsive mobile interfaces with switchable wettability, optical properties, and penetrability”, ACS Appl. Mat. Interfaces, 2017, 9, 35483-35491.
Z.-S. Wu, Y. Zheng, S. Zheng, S. Wang, C. Sun, K. Parvez, T. Ikeda, X. Bao, K. Muellen, X. Feng, “Stacked-Layer Heterostructure Films of 2D Thiophene Nanosheets and Graphene for High-Rate All-Solid-State Pseudocapacitors with Enhanced Volumetric Capacitance.” Adv. Mater., 2017, 29, 1602960.
Y. Zheng, J. Cui, T. Ikeda “Click functionalization of phenyl-capped bithiophene on azide-terminated self-assembled monolayers”, Applied Surface Science, 2015, 355, 213-217.
Y. Zheng, H. Zhou, D. Liu, F. George, W. Manfred; K. Kaloian, M. Mezger, H.-J. Butt, T. Ikeda, “Thiophene Supramolecular Nanosheet”, Angew. Chem. Int. Ed., 2013, 52, 4845-4848.
Y. Zheng, D. Liu, H.-J. Butt, T. Ikeda, “Synthesis and Properties of Phenyl-capped Cyclohexyl[c]-oligothiophenes”, Synth. Met., 2013, 181, 1-9.
Y. Zheng, J. Cui, J. Zheng, X. Wan, “Near-infrared Electrochromic and Chiroptical Switching Polymers: Synthesis and Characterization of Helical Poly(N-propargylamides) Carrying Anthraquinone Imide Moieties in Side Chains”, J. Mater. Chem., 2010, 20, 5915-5922.
Y. Zheng, K. Yao, J. Lee, D. Chandler, J. Wang, C. Wang, F. Chu, C. Tang, “Well-Defined Renewable Polymers Derived from Gum Rosin”, Macromolecules, 2010, 43, 5922-5924.
Y. Zheng, J. Zheng, L. Dou, W. Qiao, X. Wan, “Synthesis and Characterization of a Novel kind of Near-infrared Electrochromic Polymers Containing an Anthraquinone Imide Group and Ionic Moieties”, J. Mater. Chem., 2009, 19, 8470-8477.
赵鹏 助理研究员 2019年6月-2021年7月 上海交通大学 博士后 2014年9月-2021年6月 华东理工大学 博士 2010年9月-2014年6月 山东科技大学 学士 | |
蒋晓宇 博士后,上海科技大学 博士 | 周维 22级博士生,青岛科技大学 学士 |
卢彦 22级博士生,沈阳药科大学 学士 | |
赵远峰 22级博士生,北京化工大学 学士 | |
赵英帅 21级研究生,青岛科技大学 学士 | 李博涵 21级研究生, 上海科技大学 学士 |
陈劭杰 21级研究生(联合培养),山东大学 学士 邮箱:chenshj1@shanghaitech.edu.cn | 曹明慧 21级研究生, 大连理工大学 学士 |
樊晓良 22级研究生, 南京工业大学 学士 |
付晴雨 22级研究生,东北林业大学 学士 邮箱:fuqy2022@shanghaitech.edu.cn |
徐锡文 23级研究生, 山东师范大学 学士 邮箱:xuxw2023@shanghaitech.edu.cn |
刘艺程 23级研究生,山东大学 学士 |
王耀文 24级研究生,华东理工大学 学士 邮箱:wangyw2024@shanghaitech.edu.cn | 张敏玥 24级研究生,南京信息工程大学 学士 邮箱:zhangmy22024@shanghaitech.edu.cn |
2024年11月,恭喜卢彦同学喜提Nature Communications一篇
2024年11月,恭喜赵英帅和李博涵的工作发表在Angew. Chem.期刊上
2024年9月,欢迎王耀文、张敏玥、赵润萌和陈骋同学加入课题组
2023年9月,欢迎刘艺程、徐锡文和韩盛同学加入课题组
2023年3月,郑宜君获得上海市自然科学基金面上项目的资助
2022年12月,祝贺蒋晓宇博士获得上海市超级博士后计划和博士后面上基金的资助
2022年7月,欢迎蒋晓宇博士加入课题组开展博士后研究工作
2021年9月,欢迎赵英帅,李博涵,曹明慧和陈邵杰等加入课题组
2021年7月,欢迎赵鹏助理研究员加入课题组开展研究工作
2020年9月,郑宜君获得国家自然科学基金面上项目的资助
2020年9月,欢迎研究生卢彦,徐林洁同学加入课题组
2020年8月,欢迎本科生郑江楠同学加入课题组开展科研实践
2020年7月,欢迎电子科技大学博士生王宏同学进组交流
2020年7月,欢迎本科生苏睿,李小禾,曹宗宇同学进组开展科研实践
2019年12月,欢迎准研究生赵远峰同学加入课题组
2019年10月,动态生物材料课题组成立,欢迎研究生周维,程楠,张静宜同学加入课题组
2024年4月,课题组在长兴岛郊野公园团建
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