ShanghaiTech University is responsible for building the Shanghai-XFEL Beamline Project, and its Sister Project of Shanghai Soft XFEL User Facility, which together establish the a new generation of XFEL Large Shared User Facility. The projects take live cell imaging as its main innovation, involving biology, physics, chemistry, and other disciplines. Stations of Undulator Beamline, Optical Beamline, live cell imaging, physical chemistry, many other labs, and the peripheral systems will be built, integrating the most successful and cutting-edge techniques in biological research ---Fluorescence Super-resolution Optics Microscopic Imaging and X-ray Free Electron Laser Microscopic Imaging. The projects aim to explore theintracellular nano-world, and ultimately to boost the Chinese scientific community’s core competence to solve the major scientific issues in life mechanism exploration, catalytic reaction control, and artificial quantum modulation. The projects play important roles in facilitating Shanghai to be a Science and Technology Innovation Center, and in contributing to making Shanghai’s Zhangjiang Comprehensive National Science Center a highly-focused World-class Major Science and Technology Infrastructure Groups.