钟超 Chao Zhong课题组介绍

  课题组长  
钟超 Chao Zhong,助理教授、研究员 Assistant Professor, PI
通讯地址:上海市浦东新区华夏中路393号物质学院3号楼210室
电子邮件:E-mail: zhongchao@shanghaitech.edu.cn
1997年-2001年就读于天津大学材料科学专业获得学士学位;
2001年-2004年就读于北京化工大学材料科学专业获得硕士学位;
2004年-2009年就读于康奈尔大学纤维科学系,获得生物医学工程,纤维科学和材料科学博士;
2009年-2011年在华盛顿大学(西雅图)材料科学系从事博士后工作;
2012年-2014年在麻省理工学院电子和计算机工程系,生物工程系以及麻省理工合成生物学中心从事博士后工作;
2014年7月加入上海科技大学物质科学与技术学院,任助理教授,研究员,博士生导师;
2015年入选中组部“青年千人计划”与上海“曙光学者”。

1997 to 2001, Bachelor of Engineering, Materials Science, Tianjin University;
2001 to 2004, Master degree in Materials Science, BUCT, Beijing;
2004 to 2009, Ph. D. in Biomedical Engineering, Cornell University;
2009 to 2011, Post-PhD, Department of MSE, University of Washington (Seattle);
2012 to 2014, Post-PhD, Department of EECS and Department of Biological Engineering, Synthetic Biology Center, Massachusetts Institute of Technology;
2014-now PI & Assistant Professor, School of Physical Science and Technology, ShanghaiTech University;
2015 "1000 Talent Plan for Young Scientists" Award, by Chinese Central Government and "Shu Guang Plan" Award, by Shanghai Municipal Education Commission
  研究兴趣  


钟老师实验室以生物灵感工程准则为主线,以当代社会所面临的健康,能源和环境等方面的重大问题为导向,致力于下一代生物灵感材料,生物纳米技术或装置的开发和实际应用。具体包括以下几方面:1)生物和非生物界面交叉问题的探索以及相关前沿技术的开发; 2)发展新型的生物灵感性材料,生物仿生纳米技术及其在医药和其他重要技术领域的应用; 3)基于分子,细胞和组织等多级别的生物灵感分子器件和装置的开发及应用。

当前课题组的研究项目主要包括:(1)工程细菌生物膜活体功能材料及其在生物修复,生物催化,人工光合和生物医药中的应用;(2)生物粘合现象和水下粘合材料的开发;(3)基于功能淀粉样蛋白的生物自组装,生物制造以及装置整合。


The Zhong lab at the Materials and Physical Biology Division in the School of Physical Science & Technology (SPST) aims to leverage the power of synthetic biology to develop an integrative bio-inspired molecular engineering (IBME) program, through which new materials, nanotechnologies and devices are created by adapting and applying the ways that living organisms develop and function. The ultimate goal of our research is to create stimuli-responsive, self-regenerating and life-enhancing functional materials and devices by integrating synthetic biology, microbial engineering, materials science, nanotechnology and modern manufacturing tools.

Our current research efforts are mainly focused on structural amyloids, emerging molecular materials with attributes including intrinsic self-assembly, ultra-stability, outstanding mechanical properties and tunable functionalities. Traditionally considered as mis-folded structures relevant to several neurodegenerative diseases in mammals, amyloids have been increasingly recognized as functional building blocks in organisms. For example, they are closely associated with the catalysis of melanin synthesis in mammalian melanosomes; they also constitute the primary structural proteins in bacterial biofilms, and functional components of underwater adhesives in marine species.

Taking inspiration from biology, our research program in harnessing functional amyloids for new biomaterials and bionanotechnologies comprise four main thrusts:

(1) Living Functional Materials;

(2) Bio-inspired Underwater Adhesives;

(3) Dynamic Complex Assemblies and Biofabrication;

(4) Biofilms-interfaced Biocatalysis & Artificial Photosynthesis.

Our research is committed to advancing the emerging field of synthetic biology and pushing new frontiers in biomaterials research and bionanotechnologies.


(1)      Living Functional Materials


Stay Tuned !   :)


(2)      Bio-inspired Underwater Adhesives



Stay Tuned !    :)


(3)      Dynamic Complex Assemblies and Biofabrication

Biological materials and systems are replete with diverse self-assemblies, including both non-equilibrium and equilibrium systems. Self-assemblies constitute the basis of many complex supramolecular structures, providing extraordinary functional properties and playing important physiological roles for various molecular materials and biological machines. Characteristic of such biological self-assemblies is its dynamic, adaptive, and environmentally responsive nature, providing an unparalleled potential for a future repertoire of multifunctional materials and nanotechnologies.

In mimicking the diverse complex assembling systems in nature, we leveraged the intrinsic self-assembling propensity of the FUS LC domain, along with a modular genetic strategy, to construct tailor-designed supramolecular structures with variable functionalities. We demonstrate that this integrative strategy is suitable for creating random copolymer-like, multi-block, and self-sorted supramolecular fibers that displayed distinct fluorescent functionalities and allowed the spatially controlled assembly of nano-objects in structure-dependent fashions (Illustrated in A).


(4)      Biofilms-interfaced Biocatalysis & Artificial Photosynthesis


Stay Tuned !   :)


  新闻动态  

1. Jan 2018 A communication paper titled “Programming Cells for Dynamic Assembly of Inorganic Nano-objects with Spatiotemporal Control"has been accepted for publication in Advanced Materials. (Congrats to Xinyu Wang, Jiahua Pu and Bolin An!)

通讯文章 “Programming Cells for Dynamic Assembly of Inorganic Nano-objects with Spatiotemporal Control” 被先进材料接受,恭喜博士生王新宇、濮嘉华和安柏霖!

2. Jan 2018 A collaborative paper “Programming Integrative Extracellular and Intracellular Biocatalysis for Rapid, Robust, and Recyclable Synthesis of Trehalose” has been accepted for publication in ACS Catalysis.  (In collaboration with Dr. Ling Jang and Dr. He Huang @Nanjing Tech).

与南京工大的合作文章 “Programming Integrative Extracellular and Intracellular Biocatalysis for Rapid, Robust, and Recyclable Synthesis of Trehalose” 被ACS Catalysis接收。(合作者:南京工业大学黄和教授与江凌博士)

3. Dec 2017 A farewell party for postdoc Xiuhai Mao and Mr. Tianxin Zhao (graduation with a master degree), Special thanks for their contributions to IBME.

毛秀海博士和赵田鑫的告别欢送聚会——火锅欢送会, IBME课题组感谢他们的贡献并祝愿他们前程似景!

4. Dec 2017 In collaboration with Professor Timothy K. Lu group at MIT, the Zhong group has recently been awarded “the MIT Greater China Fund for Innovation”. The funding supports collaborations between faculty at MIT and their counterparts in China, Hong Kong and Taiwan.

5. Nov 2017 Dr. Zhong’s expert comment on recent work published inAdvanced Materials Interfacesappeared in  “Inside Science”

6. Oct 2017 Dr. Zhong’s expert comment on recent work published in Science Advances appeared in Science News.
7. Oct 2017 崔孟奎、任苏苏及魏世操以“Natural and Bio-inspired Underwater Adhesives: Current Progress and New Perspectives”为题的文章,被 APL Materials接收。

8. Sept 2017 上海科技大学成功承办第295期东方科技论坛。

9. July 2017 15级硕士研究生张琛(右三)在第三届合成生物学青年学者论坛获“优秀墙报奖”。

10. July 2017 博士研究生安柏霖与王新宇以“Diverse Supramolecular Nanofiber Networks Made by Complex Assembly of Functional Low-Complexity Domains”为题的文章,被 ACS NANO 接收。

11. Oct 2016 钟超老师携2014级本科生在2016年国际基因工程机器大赛(the International Genetically Engineered Machine Competition, iGEM)荣获金奖。

12. Spring 2015 Dr. Zhong’s expert comment on recent work about underwater adhesives appeared in Nature Outlook.


  信息发布  

1.【人员招聘】实验室诚招材料科学, 化学,微生物学,生物化工以及合成生物学和纳米技术等背景博士后1名。

2.【学生工作】长期欢迎生物、材料、化学、微生物等相关专业,对生物仿生材料及生物灵感纳米材料感兴趣的本科生,加入我们!

  代表论文  


  1. Ling Jiang, Xiaogang Song, Yingfeng Li, Qing Xu, Jiahua Pu, He Huang*, and Chao Zhong*. Programming Integrative Extracellular and Intracellular Biocatalysis for Rapid, Robust, and Recyclable Synthesis of Trehalose, ACS Catalysis 2018, 8, 1837−1842.
  2. Xinyu Wang#, Jiahua Pu#, Bolin An#, Yingfeng Li, Yuequn Shang, Zhijun Ning, Yi Liu, Fang Ba, Jiaming Zhang, Chao Zhong*. Programming Cells for Dynamic Assembly of Inorganic Nano-objects with Spatiotemporal Control. Advanced Materials, In press.
  3. Bolin An#, Xinyu Wang#, et al. and Chao Zhong*, Diverse Supramolecular Nanofiber Networks Assembled by Functional Low-Complexity Domains. ACS Nano 2017, 11(7), 6985-6995.
  4. M. K. Cui#, S.S. Ren#, S. C. Wei#, C. J. Sun and C. Zhong*, Natural and Bio-inspired Underwater Adhesives: Current Progress and New Perspectives. APL Materials 2017, 5, 116102.
  5. X. Y. Wang, Y. F. Li, C. Zhong*, Amyloid-directed assembly of nanostructures and functional devices for bionanoelectronics. Journal of Materials Chemistry B 2015, 3, 4953-4958. (Invited mini-review).
  6. A. Chen, C. Zhong, T. K. Lu. Engineering living functional Materials, ACS Synthetic Biology 2015, 4, 8-11. (Perspective paper)
  7. C. Zhong, T. K. Lu et al. Strong underwater adhesives made by self-assembling multi-protein nanofibres. Nature Nanotechnology 2014, 10, 858-866. (Highlighted in MIT News, the Scientist, Science Daily, Materials Today, MRS website and others)
  8. C. Zhong, Y. X. Deng, A. Kapetanovic, M. Rolandi, A polysaccharide bioprotonic field-effect transistor. Nature Communications 2011, 2, 476. (Highlighted by MIT Tech Review, IEEE Spectrum, MRS website and others).
  9. C. Zhong, A.Kapetanovic, Y. X. Deng, M. Rolandi, A chitin nanofiber ink for airbrushing, replica molding and microcontact printing of self-assembled macro-, micro- and nanostructures. Advanced Materials 2011, 23, 4776-4781. (Inside cover feature)
  10. C. Zhong, C.C.Chu, Biomimetic mineralization of acid polysaccharide-based hydrogels: Towards porous 3-dimensional bone-like biocomposites. Journal of Materials Chemistry 2012, 22, 6080-6087. (Highlighted in Biomimetic Materials Collection on RSC Biomaterials Science Blog).
  11. C. Zhong, C. C. Chu et al., Synthesis, characterization and cytotoxicity of photo-crosslinked maleic chitosan-PEGDA hybrid hydrogels. Acta Biomaterialia 2010, 6, 3908-3918.
  12. C. Zhong, M. Rolandi et al., A facile bottom-up route to self-assembled biogenic chitin nanofibers. Soft Matter 2010, 6, 5298-5301.




(#equal contribution   * corresponding author)

  课题组成员合照  
  Alumni  

锜琦 2016届

赵田鑫 2017届

毛秀海 博士后

  本组成员  

黄娇芳 助理研究员

Living Functional Materials
Microbial Metabolism and Regulation

 

邮箱:huangjf@shanghaitech.edu.cn

安柏霖 博士

Living cellular glues Self-assemble Supramolecular Nanostructures

 HFUT

邮箱:anbl@shanghaitech.edu.cn

崔孟奎 博士

Bio-inspired Underwater Adhesives
Intermolecular Interaction

 SEU

邮箱:cuimk@shanghaitech.edu.cn

李柯 博士

Synthetic Biology Functional Biofilms
Bio-minerlization

 NEFU

邮箱:like@shanghaitech.edu.cn

李颖风 博士

Microfabrication Bionanotechnology
Synthetic Biology

 TJU

邮箱:liyf@shanghaitech.edu.cn

刘苏莹 博士

Living Functional Materials
Microbial Metabolism and Regulation

 SPU

邮箱:liusy @shanghaitech.edu.cn

濮嘉华 博士

Artificial photosynthesis

 ECNU

邮箱:pujh@shanghaitech.edu.cn

王新宇 博士

Bio-inorganic Interface
Biocatalysis

 ZZU

邮箱:wangxy@shanghaitech.edu.cn

蒋晓宇 硕士

Stay Tuned ! :)

 NJTech

邮箱:jiangxy@shanghaitech.edu.cn

任苏苏 硕士

Underwater Adhesives

 CUMT

邮箱:renss@shanghaitech.edu.cn

王艳怡 硕士

Self-assembling Supramolecular Nanostructures

 HNU

邮箱:wangyy1@shanghaitech.edu.cn

魏世操 硕士

Functional Biofilms

 CPU

邮箱:weisc@shanghaitech.edu.cn

张琛 硕士

Synthetic Biology Underwater Adhesives
Biofilm Mechanics

 HUST

邮箱:zhangchen@shanghaitech.edu.cn

张继聪 硕士

Stay Tuned ! :)

 UJN

邮箱:zhangjc@shanghaitech.edu.cn

刘奕 推免生

 ShanghaiTech

邮箱:liuyi@shanghaitech.edu.cn

巴方 本科生

Artificial photosynthesis

 

邮箱:bafang@shanghaitech.edu.cn

杜君薇 本科生

Artificial Photosynthesis

 

邮箱:dujw@shanghaitech.edu.cn

谢余 本科生

Functional Protein & Supermolecular Structure

 

邮箱:xieyu@shanghaitech.edu.cn

张韵豪 本科生

 

邮箱:zhangyh@shanghaitech.edu.cn

辛美玲 技术员

 

邮箱:xinml@shanghaitech.edu.cn