钟超 Chao Zhong课题组介绍
钟老师实验室以生物灵感工程准则为主线，以当代社会所面临的健康，能源和环境等方面的重大问题为导向，致力于下一代生物灵感材料，生物纳米技术或装置的开发和实际应用。具体包括以下几方面：1）生物和非生物界面交叉问题的探索以及相关前沿技术的开发； 2）发展新型的生物灵感性材料，生物仿生纳米技术及其在医药和其他重要技术领域的应用； 3）基于分子，细胞和组织等多级别的生物灵感分子器件和装置的开发及应用。
The Zhong lab at the Materials and Physical Biology Division in the School of Physical Science & Technology (SPST) aims to leverage the power of synthetic biology to develop an integrative bio-inspired molecular engineering (IBME) program, through which new materials, nanotechnologies and devices are created by adapting and applying the ways that living organisms develop and function. The ultimate goal of our research is to create stimuli-responsive, self-regenerating and life-enhancing functional materials and devices by integrating synthetic biology, microbial engineering, materials science, nanotechnology and modern manufacturing tools.
Our current research efforts are mainly focused on structural amyloids, emerging molecular materials with attributes including intrinsic self-assembly, ultra-stability, outstanding mechanical properties and tunable functionalities. Traditionally considered as mis-folded structures relevant to several neurodegenerative diseases in mammals, amyloids have been increasingly recognized as functional building blocks in organisms. For example, they are closely associated with the catalysis of melanin synthesis in mammalian melanosomes; they also constitute the primary structural proteins in bacterial biofilms, and functional components of underwater adhesives in marine species.
Taking inspiration from biology, our research program in harnessing functional amyloids for new biomaterials and bionanotechnologies comprise four main thrusts:
(1) Living Functional Materials;
(2) Bio-inspired Underwater Adhesives;
(3) Dynamic Complex Assemblies and Biofabrication;
(4) Biofilms-interfaced Biocatalysis & Artificial Photosynthesis.
Our research is committed to advancing the emerging field of synthetic biology and pushing new frontiers in biomaterials research and bionanotechnologies.
(1) Living Functional Materials
Stay Tuned ! ：）
(2) Bio-inspired Underwater Adhesives
Stay Tuned ! ：）
(3) Dynamic Complex Assemblies and Biofabrication
Biological materials and systems are replete with diverse self-assemblies, including both non-equilibrium and equilibrium systems. Self-assemblies constitute the basis of many complex supramolecular structures, providing extraordinary functional properties and playing important physiological roles for various molecular materials and biological machines. Characteristic of such biological self-assemblies is its dynamic, adaptive, and environmentally responsive nature, providing an unparalleled potential for a future repertoire of multifunctional materials and nanotechnologies.
In mimicking the diverse complex assembling systems in nature, we leveraged the intrinsic self-assembling propensity of the FUS LC domain, along with a modular genetic strategy, to construct tailor-designed supramolecular structures with variable functionalities. We demonstrate that this integrative strategy is suitable for creating random copolymer-like, multi-block, and self-sorted supramolecular fibers that displayed distinct fluorescent functionalities and allowed the spatially controlled assembly of nano-objects in structure-dependent fashions (Illustrated in A).
(4) Biofilms-interfaced Biocatalysis & Artificial Photosynthesis
Stay Tuned ! ：）
June 2018 A farewell party for Chen Zhang, Susu Ren (graduation with a master degree) and undergraduate student Junwei Du, Special thanks for their contributions to IBME.
June 2018 A collaborative paper “Adhesive Bacterial Amyloid Nanofibers-Mediated Growth of Metal-Organic Frameworks on Diverse Polymeric Substrates” has been accepted for publication in Chemical Science. (In collaboration with Tao Li @ ShanghaitTech).
与李涛老师的合作文章 “Adhesive Bacterial Amyloid Nanofibers-Mediated Growth of Metal-Organic Frameworks on Diverse Polymeric Substrates” 被 Chemical Science 接收。
June 2018 Professor Zhong and three Ph.D students Yingfeng Li, Xinyu Wang and Bolin An attended the Gordon Research Conference (GRC) Bioinspired Multifunctional Dynamic Materials held in Switzerland(Les Diablerets Conference Center) from June 24 to 29, 2018. The three students made poster presentations, with the titles below:
Yingfeng Li “An amyloid-based fundamental building material with integrated genetically programmable functionality”
Xinyu Wang “Programming Cells for Dynamic Assembly of Inorganic Nano-objects with Spatiotemporal Control”
Bolin An “Engineering Living Cellular Glues with Synthetic Biology”
Prof. Zhong has been selected and recommended by the GRC Chair to present a short talk 'Engineering Living Cellular Glues with Synthetic Biology' at the Gordon Research Conference (GRC) Bioinspired Multifunctional Dynamic Materials.
钟老师被Gordon Research Conference (GRC) Bioinspired Multifunctional Dynamic Materials会议主席邀请做题为'Engineering Living cellular glues with synthetic biology' 的short talk。
June 2018 Our work published in Advanced Materials has been highlighted in Advanced News. Check the VEDIO highlight following the link below.
April 2018 Mr. Xinyu Wang, a senior Ph.D student, gave an oral presentation titled “Dynamic Bio-abiotic Hybrid Structures: Constructions and Applications” at the 7th Spring World Congress on Engineering and Technology (SCET 2018) on April 23 in Guilin, China.
2013级博士生王新宇参加于4月23-24号在桂林召开的2018年第七届春季国际工程与技术大会，并作题为“Dynamic Bio-abiotic Hybrid Structures: Constructions and Applications”报告。
April 2018 A communication paper titled “Programming Cells for Dynamic Assembly of Inorganic Nano-objects with Spatiotemporal Control” has now been published online in Advanced Materials (selected as inside back cover and highlighted in video abstract on the official website!)
通讯文章 “Programming Cells for Dynamic Assembly of Inorganic Nano-objects with Spatiotemporal Control”被在先进材料在线发表，并入选同期的内封面。该文章被先进材料编辑推荐在官方网站的视频摘要(video abstract) 中进行重点介绍。
相关媒体报道：学 校 新 闻：物质学院钟超课题组开发出智能细菌，可时空调控无机纳米材料的动态自组装
澎 湃 新 闻：生物智造：中国科学家打一束光，让细菌“打工”画纳米电路
CBG 资 讯：上海科技大学钟超研究员团队: 利用智能细菌时空调控无机纳米材料的动态自组装
材 料 牛：Adv. Mater.：用于动态组装无机纳米物体的编程单元
生 物 极 客：上科大钟超课题组先进材料发表文章借助细菌实现时空纳米材料组装
长 江 日 报：用一束光让细菌“干活” 未来你用的手机屏可能是细菌生产
April 2018 An invited review paper “Emerging Paradigms for Synthetic Design of Functional Amyloids” has been accepted for publication in Journal of Molecular Biology, in the upcoming theme issue “functional amyloids”. (Congrats to Yanyi Wang, Jiahua Pu and Bolin An!).
邀请综述文章“Emerging Paradigms for Synthetic Design of Functional Amyloids”被Journal of Molecular Biology接收，恭喜王艳怡、濮嘉华和安柏霖！
Jan 2018 A communication paper titled “Programming Cells for Dynamic Assembly of Inorganic Nano-objects with Spatiotemporal Control” has been accepted for publication in Advanced Materials. (Congrats to Xinyu Wang, Jiahua Pu and Bolin An!)
通讯文章 “Programming Cells for Dynamic Assembly of Inorganic Nano-objects with Spatiotemporal Control” 被先进材料接受，恭喜博士生王新宇、濮嘉华和安柏霖！
Jan 2018 A collaborative paper “Programming Integrative Extracellular and Intracellular Biocatalysis for Rapid, Robust, and Recyclable Synthesis of Trehalose” has been accepted for publication in ACS Catalysis. (In collaboration with Dr. Ling Jang and Dr. He Huang @Nanjing Tech).
与南京工大的合作文章 “Programming Integrative Extracellular and Intracellular Biocatalysis for Rapid, Robust, and Recyclable Synthesis of Trehalose” 被ACS Catalysis接收。（合作者：南京工业大学黄和教授与江凌博士）
Dec 2017 A farewell party for postdoc Xiuhai Mao and Mr. Tianxin Zhao (graduation with a master degree), Special thanks for their contributions to IBME.
Dec 2017 In collaboration with Professor Timothy K. Lu group at MIT, the Zhong group has recently been awarded “the MIT Greater China Fund for Innovation”. The funding supports collaborations between faculty at MIT and their counterparts in China, Hong Kong and Taiwan.
Sept 2017 上海科技大学成功承办第295期东方科技论坛。
July 2017 15级硕士研究生张琛（右三）在第三届合成生物学青年学者论坛获“优秀墙报奖”。
Microbial Metabolism and Regulation
Microbial Metabolism and Regulation